| Pegasus World Cup Invitational Stakes | Jan 23, 2021 | Gulfstream Park | 3UP R D | 3U | | 9.0 | Main | 1 |
| Pegasus World Cup Turf Invitational Stakes | Jan 23, 2021 | Gulfstream Park | 3UP R T | 3U | | 9.5 | T | 1 |
| Santa Anita Handicap | Mar 6, 2021 | Santa Anita | 3UP R D | 3U | | 10.0 | Main | 1 |
| Frank E Kilroe Mile Stakes | Mar 6, 2021 | Santa Anita | 3UP R T | 3U | | 8.0 | T | 1 |
| Beholder Mile Stakes | Mar 13, 2021 | Santa Anita | 3UP F/M RD | 3U | f | 8.0 | Main | 1 |
| Curlin Florida Derby | Mar 27, 2021 | Gulfstream Park | 3YO R D | 3 | | 9.0 | Main | 1 |
| Carter Handicap | Apr 3, 2021 | Aqueduct | 3UP SPR | 3U | | 7.0 | Main | 1 |
| Runhappy Santa Anita Derby | Apr 3, 2021 | Santa Anita | 3YO R D | 3 | | 9.0 | Main | 1 |
| Madison Stakes | Apr 3, 2021 | Keeneland | 3UP F/M SPR | 3U | f | 7.0 | Main | 1 |
| Ashland Stakes | Apr 3, 2021 | Keeneland | 3YO F R D | 3 | f | 8.5 | Main | 1 |
| Makers Mark Mile Stakes | Apr 9, 2021 | Keeneland | 3UP R T | 3U | | 8.0 | T | 1 |
| Arkansas Derby | Apr 10, 2021 | Oaklawn Park | 3YO R D | 3 | | 9.0 | Main | 1 |
| Coolmore Jenny Wiley Stakes | Apr 10, 2021 | Keeneland | 3UP F/M RT | 3U | f | 8.5 | T | 1 |
| Apple Blossom Handicap | Apr 17, 2021 | Oaklawn Park | 3UP F/M RD | 3U | f | 8.5 | Main | 1 |
| Kentucky Oaks | Apr 30, 2021 | Churchill Downs | 3YO F R D | 3 | f | 9.0 | Main | 1 |
| La Troienne Stakes | Apr 30, 2021 | Churchill Downs | 3UP F/M RD | 3U | f | 8.5 | Main | 1 |
| Kentucky Derby | May 1, 2021 | Churchill Downs | 3YO R D | 3 | | 10.0 | Main | 1 |
| Derby City Distaff | May 1, 2021 | Churchill Downs | 3UP F/M SPR | 3U | f | 7.0 | Main | 1 |
| Old Forester Bourbon Turf Classic Stakes | May 1, 2021 | Churchill Downs | 3UP R T | 3U | | 9.0 | T | 1 |
| Churchill Downs Stakes | May 1, 2021 | Churchill Downs | 3UP SPR | 3U | | 7.0 | Main | 1 |
| Man O War Stakes | May 8, 2021 | Belmont Park | 3UP R T | 3U | | 11.0 | T | 1 |
| Preakness Stakes | May 15, 2021 | Pimlico | 3YO R D | 3 | | 9.5 | Main | 1 |
| Gamely Stakes | May 31, 2021 | Santa Anita | 3UP F/M RT | 3U | f | 9.0 | T | 1 |
| Hollywood Gold Cup Stakes | May 31, 2021 | Santa Anita | 3UP R D | 3U | | 10.0 | Main | 1 |
| Shoemaker Mile Stakes | May 31, 2021 | Santa Anita | 3UP R T | 3U | | 8.0 | T | 1 |
| Belmont Stakes | Jun 5, 2021 | Belmont Park | 3YO R D | 3 | | 12.0 | Main | 1 |
| Ogden Phipps Stakes | Jun 5, 2021 | Belmont Park | 3UP F/M RD | 3U | f | 8.5 | Main | 1 |
| Just A Game Stakes | Jun 5, 2021 | Belmont Park | 3UP F/M RT | 3U | f | 8.0 | T | 1 |
| Hill N Dale Metropolitan Handicap | Jun 5, 2021 | Belmont Park | 3UP R D | 3U | | 8.0 | Main | 1 |
| Resorts World Casino Manhattan Stakes | Jun 5, 2021 | Belmont Park | 3UP R T | 3U | | 10.0 | T | 1 |
| Jackpocket Jaipur Stakes | Jun 5, 2021 | Belmont Park | 3UP T SPR | 3U | | 6.0 | T | 1 |
| Acorn Stakes | Jun 5, 2021 | Belmont Park | 3YO F R D | 3 | f | 8.0 | Main | 1 |
| Woody Stephens Stakes | Jun 5, 2021 | Belmont Park | 3YO SPR | 3 | | 7.0 | Main | 1 |
| Belmont Oaks Invitational Stakes | Jul 10, 2021 | Belmont Park | 3YO F R T | 3 | f | 10.0 | T | 1 |
| Belmont Derby Invitational Stakes | Jul 10, 2021 | Belmont Park | 3YO R T | 3 | | 10.0 | T | 1 |
| Diana Stakes | Jul 17, 2021 | Saratoga | 3UP F/M RT | 3U | f | 9.0 | T | 1 |
| United Nations Stakes | Jul 17, 2021 | Monmouth Park | 3UP R T | 3U | | 11.0 | T | 1 |
| Haskell Stakes | Jul 17, 2021 | Monmouth Park | 3YO R D | 3 | | 9.0 | Main | 1 |
| Coaching Club American Oaks | Jul 24, 2021 | Saratoga | 3YO F R D | 3 | f | 9.0 | Main | 1 |
| Alfred G Vanderbilt Handicap | Jul 31, 2021 | Saratoga | 3UP SPR | 3U | | 6.0 | Main | 1 |
| Bing Crosby Stakes | Jul 31, 2021 | Del Mar | 3UP SPR | 3U | | 6.0 | Main | 1 |
| Clement L Hirsch Stakes | Aug 1, 2021 | Del Mar | 3UP F/M RD | 3U | f | 8.5 | Main | 1 |
| Whitney Stakes | Aug 7, 2021 | Saratoga | 3UP R D | 3U | | 9.0 | Main | 1 |
| Test Stakes | Aug 7, 2021 | Saratoga | 3YO F SPR | 3 | f | 7.0 | Main | 1 |
| Saratoga Derby Invitational Stakes | Aug 7, 2021 | Saratoga | 3YO R T | 3 | | 9.5 | T | 1 |
| Beverly D Stakes | Aug 14, 2021 | Arlington Park | 3UP F/M RT | 3U | f | 9.5 | T | 1 |
| Mister D Stakes | Aug 14, 2021 | Arlington Park | 3UP R T | 3U | | 10.0 | T | 1 |
| Bruce D Stakes | Aug 14, 2021 | Arlington Park | 3YO R T | 3 | | 8.0 | T | 1 |
| Fourstardave Handicap | Aug 14, 2021 | Saratoga | 3UP R T | 3U | | 8.0 | T | 1 |
| Alabama Stakes | Aug 21, 2021 | Saratoga | 3YO F R D | 3 | f | 10.0 | Main | 1 |
| Pacific Classic Stakes | Aug 21, 2021 | Del Mar | 3UP R D | 3U | | 10.0 | Main | 1 |
| Del Mar Oaks | Aug 21, 2021 | Del Mar | 3YO F R T | 3 | f | 9.0 | T | 1 |
| Personal Ensign Stakes | Aug 28, 2021 | Saratoga | 3UP F/M RD | 3U | f | 9.0 | Main | 1 |
| Ballerina Handicap | Aug 28, 2021 | Saratoga | 3UP F/M SPR | 3U | f | 7.0 | Main | 1 |
| Sword Dancer Stakes | Aug 28, 2021 | Saratoga | 3UP R T | 3U | | 12.0 | T | 1 |
| Forego Stakes | Aug 28, 2021 | Saratoga | 3UP SPR | 3U | | 7.0 | Main | 1 |
| Travers Stakes | Aug 28, 2021 | Saratoga | 3YO R D | 3 | | 10.0 | Main | 1 |
| Handicap Allen Jerkens Stakes | Aug 28, 2021 | Saratoga | 3YO SPR | 3 | | 7.0 | Main | 1 |
| Flower Bowl Stakes | Sep 4, 2021 | Saratoga | 3UP F/M RT | 3U | f | 11.0 | T | 1 |
| Jockey Club Gold Cup Stakes | Sep 4, 2021 | Saratoga | 3UP R D | 3U | | 10.0 | Main | 1 |
| Spinaway Stakes | Sep 5, 2021 | Saratoga | 2YO F | 2 | f | 7.0 | Main | 1 |
| Del Mar Debutante Stakes | Sep 5, 2021 | Del Mar | 2YO F | 2 | f | 7.0 | Main | 1 |
| Hopeful Stakes | Sep 6, 2021 | Saratoga | 2YO | 2 | | 7.0 | Main | 1 |
| Runhappy Del Mar Futurity | Sep 6, 2021 | Del Mar | 2YO | 2 | | 7.0 | Main | 1 |
| Cotillion Stakes | Sep 25, 2021 | Parx Racing | 3YO F R D | 3 | f | 8.5 | Main | 1 |
| Pennsylvania Derby | Sep 25, 2021 | Parx Racing | 3YO R D | 3 | | 9.0 | Main | 1 |
| American Pharoah Stakes | Oct 1, 2021 | Santa Anita | 2YO | 2 | | 8.5 | Main | 1 |
| Rodeo Drive Stakes | Oct 2, 2021 | Santa Anita | 3UP F/M RT | 3U | f | 10.0 | T | 1 |
| Awesome Again Stakes | Oct 2, 2021 | Santa Anita | 3UP R D | 3U | | 9.0 | Main | 1 |
| Champagne Stakes | Oct 2, 2021 | Belmont Park | 2YO | 2 | | 8.0 | Main | 1 |
| Woodward Stakes | Oct 2, 2021 | Belmont Park | 3UP R D | 3U | | 9.0 | Main | 1 |
| Frizette Stakes | Oct 3, 2021 | Belmont Park | 2YO F | 2 | f | 8.0 | Main | 1 |
| Darley Alcibiades Stakes | Oct 8, 2021 | Keeneland | 2YO F | 2 | f | 8.5 | Main | 1 |
| Claiborne Breeders Futurity | Oct 9, 2021 | Keeneland | 2YO | 2 | | 8.5 | Main | 1 |
| First Lady Stakes | Oct 9, 2021 | Keeneland | 3UP F/M RT | 3U | f | 8.0 | T | 1 |
| Keeneland Turf Mile Stakes | Oct 9, 2021 | Keeneland | 3UP R T | 3U | | 8.0 | T | 1 |
| Joe Hirsch Turf Classic Stakes | Oct 9, 2021 | Belmont Park | 3UP R T | 3U | | 12.0 | T | 1 |
| Juddmonte Spinster Stakes | Oct 10, 2021 | Keeneland | 3UP F/M RD | 3U | f | 9.0 | Main | 1 |
| Queen Elizabeth Ii Challenge Cup Stakes | Oct 16, 2021 | Keeneland | 3YO F R T | 3 | f | 9.0 | T | 1 |
| Cigar Mile Handicap | Dec 4, 2021 | Aqueduct | 3UP R D | 3U | | 8.0 | Main | 1 |
| Clark Stakes | TBD | Churchill Downs | 3UP R D | 3U | | 9.0 | Main | 1 |
| Breeders Cup Juvenile | TBD | Del Mar | 2YO | 2 | | 8.5 | Main | 1 |
| Breeders Cup Juvenile Turf | TBD | Del Mar | 2YO | 2 | | 8.0 | T | 1 |
| Breeders Cup Juvenile Fillies | TBD | Del Mar | 2YO F | 2 | f | 8.5 | Main | 1 |
| Breeders Cup Juvenile Fillies Turf | TBD | Del Mar | 2YO F | 2 | f | 8.0 | T | 1 |
| Breeders Cup Distaff | TBD | Del Mar | 3UP F/M RD | 3U | f | 9.0 | Main | 1 |
| Breeders Cup Filly And Mare Turf | TBD | Del Mar | 3UP F/M RT | 3U | f | 11.0 | T | 1 |
| Matriarch Stakes | TBD | Del Mar | 3UP F/M RT | 3U | f | 8.0 | T | 1 |
| Breeders Cup Filly And Mare Sprint | TBD | Del Mar | 3UP F/M SPR | 3U | f | 7.0 | Main | 1 |
| Breeders Cup Classic | TBD | Del Mar | 3UP R D | 3U | | 10.0 | Main | 1 |
| Breeders Cup Dirt Mile | TBD | Del Mar | 3UP R D | 3U | | 8.0 | Main | 1 |
| Breeders Cup Turf | TBD | Del Mar | 3UP R T | 3U | | 12.0 | T | 1 |
| Breeders Cup Mile | TBD | Del Mar | 3UP R T | 3U | | 8.0 | T | 1 |
| Breeders Cup Sprint | TBD | Del Mar | 3UP SPR | 3U | | 6.0 | Main | 1 |
| Breeders Cup Turf Sprint | TBD | Del Mar | 3UP T SPR | 3U | | 5.0 | T | 1 |
| Hollywood Derby | TBD | Del Mar | 3YO R T | 3 | | 9.0 | T | 1 |
| Starlet Stakes | TBD | Los Alamitos | 2YO F | 2 | f | 8.5 | Main | 1 |
| American Oaks | TBD | Santa Anita | 3YO F R T | 3 | f | 10.0 | T | 1 |
| La Brea Stakes | TBD | Santa Anita | 3YO F SPR | 3 | f | 7.0 | Main | 1 |
| Malibu Stakes | TBD | Santa Anita | 3YO SPR | 3 | | 7.0 | Main | 1 |